Twenty four wistar strain albino rats were used for the investigations. This was demonstrated by reducing the elevated levels of biochemical markers and additional histopathological observations have shown that there is an improvement in the structural design of liver due to induced hepatotoxicity. Hepatoprotective and antioxidant capacity of mallotus. To evaluate the hepatoprotective activity of spices, 21 different spices were fed to rats with liver damage caused by lipopolysaccharide lps plus dgalactosamine dgaln. Dgalactosamine is hepatotoxic and is used, alone or in combination with lps, as a model of liver failure in rodents.
Hepatotoxic effect of dgalactosamine and protective role. Objective of this study was to obtain a better understanding of the mechanism responsible for the dgalactosamine dgaln induced hepatotoxicity and to study the effect of catechin against dgaln induced hepatotoxicity. Influence of alpha lipoic acid on antioxidant status in d. In our current study, we explored the role of pdcd4 in acute liver injury induced by lipopolysaccharide lps and dgalactosamine dgaln using. Dgalactosamine galn induced liver injury is associated with reactive oxygen species and oxidative stress. Hepatoprotective activity of lepidium sativum seeds. Curcumin attenuates dgalactosaminelipopolysaccharide. Hepatoprotective activity of lepidium sativum seeds against dgalactosamine. As the major active ingredient of cordyceps militaris, cordycepin 3. Hepatoprotective activity of lepidium sativum seeds against d. Dgalnlps treatment was able to induce hepatotoxicity and significantly increase all markers of liver damage and lipid peroxidation. To explore the potential protective effect of cordycepin in fulminant hepatic failure, mice were pretreated with cordycepin for 3 weeks followed by dgalactosamine galnlipopolysaccharide lps injection. In the present study, we aimed to complement preceding reports on the tlrldgaln system by analyzing comparisons among tlrls, mouse strain dependence, effects on serum levels of cytokines, and effects of sequential administrations of different tlrls.
In vivo hepatoprotective activity of esmr was examined using dgalactosamine dgaln induced hepatotoxicity in spraguedawley rats. View enhanced pdf access article on wiley online library html view download pdf. Most of drug withdraw from the market or pending for approval due to causing hepatotoxicity leflunomide, flutamide, disulphiram, and triglitazone and may be chance to criticize the use based on. Licochalcone a lico a, isolated from xinjiang licorice glycyrrhiza inflate, has been shown to have antioxidative potential via the activation of nuclear factorerythroid 2related factor 2 nrf2. Whole plant aqueous extractshade dried and coarsely powdered. Acetylbergenin was synthesized from acetylation of bergenin, isolated from mallotus japonicus, to increase lipophilic and physiological activities. In this study its beneficial dietary effect against liver injuries caused by dgalactosamine dgaln was studied ensuring safety to human health using animal model. Bifidobacterium longum r0175 protects rats against d. Pdf dgalactosaminelipopolysaccharideinduced hepatotoxicity. The protective effect of cordycepin on dgalactosamine.
Screening of hepatoprotective activity of madhuca longifolia bark on dgalactosamine induced hepatotoxicity in rats. Glycine and uridine prevent dgalactosamine hepatotoxicity in the rat. Lecithin 50 and 100 mgkg b wt was administered for 1 week by oral route. Liver injury was assessed biochemically and histologically. Hepatoprotective effects of purple potato extract against. Therefore, these results suggest that acetylbergenin has hepatoprotective effects against galninduced hepatotoxicity by inhibiting lipid peroxidation and. Multiple factors contribute to hepatic failure, including excessive use of alcohol, viral infection, liver transplant failure, the side effects of chemical drugs, and the metabolism of xenobiotics. Dgaln dgalactosamine and lipopolysaccharide lps were dissolved in physiological solution 0. Hepatoprotective activity of santolina chamaecyparissus linn against dgalactosamine induced hepatotoxicity in rats. Acute hepatotoxicity was induced in wister rats with dgaln followed by treatment with butylated hydroxytoluene bht and with spirulina. We demonstrated the expression of antioxidative enzyme and cytokines in plasma. This study was designed to investigate the hepatoprotective and antioxidant properties of carvacrol on d.
Protective effect of pinitol against dgalactosamine induced hepatotoxicity in rats fed on a highfat diet. Protective effect of wild ginseng cambial meristematic cells on dgalactosamine induced hepatotoxicity in rats. As assessed by plasma aminotranferase activities, nutmeg showed the most potent hepatoprotective activity. In order to download, print or access these formats you must be logged in. Dgalactosaminelipopolysaccharideinduced hepatotoxicity. Frontiers asiatic acid exhibits antiinflammatory and. Effects of acetylbergenin against d galactosamineinduced. Kannadasan 2, ramji gupta 1, 2 department of pharmacology, 1shree dhanvantary pharmacy college, kim, surat, gujarat, india 2anna university, chennai, tamilnadu, india abstract. For this purpose, levels of serum diagnostic markers, activity of hepatic antioxidant enzymes, and liver histoarchitecture. College of pharmacy, uthangudi, madurai 625017, tamil nadu, india. In fact, an experimental model of liver failure induced by d. Additionally, antisera to tumor necrosis factor tnf prevented hepatotoxicity caused byd. Acute hepatotoxicity rat model was induced by lipopolysaccharide lps 30. Glycine and uridine prevent dgalactosamine hepatotoxicity.
Protective role of catechin on d galactosamine induced. D galactosaminelipopolysaccharideinduced hepatotoxicity. Hepatoprotective and antioxidant activity of leucas aspera against d. The hepatoprotective effects of acetylbergenin were examined against dgalactosamine galn induced liver damage in rats, compared with that of bergenin reported previously. In this study, we investigated the protective effects of aa against lipopolysaccharide lps and d. Protective role of catechin on dgalactosamine induced. Modulation of dgalactosaminelipopolysacharrideinduced. The involvement of heme oxygenase 1 but not nitric oxide synthase 2 in a hepatoprotective action of quercetin in lipopolysaccharide induced hepatotoxicity of dgalactosamine sensitized rats. Acute hepatic failure is clinically characterized by massive hepatocyte apoptosis and very high patient mortality. Bioassayguided isolation of the active compound from nutmeg was carried out in mice by a single oral.
Ppe 400 mg was administered once daily for 8 d, and then galn 250 mgkg of body weight was injected at 22 h before the rats were killed. Antiinflammatory, antioxidant and antihepatotoxic effects. Methods hepatotoxicity was induced by an intraperitoneal injection of d. Thurman1,3 extrahepatic factors, such as increased gut permeability and bacteria from the gut, have been shown to play a role in. Spirulina platensis has been advocated as safe food for human use by several investigators. Liver damage was induced by intra peritoneal administration of 400 mgkg b wt dgalactosamine on the. Dgalactosamine dgaln is a well known hepatotoxicant. Asiatic acid aa, which is a pentacyclic triterpene that widely occurs in various vegetables and fruits, has been reported to possess antioxidant and antiinflammatory properties. Antiinflammatory, antioxidant and antihepatotoxic effects of spirulina platensis against dgalactosamine induced hepatotoxicity in rats. We investigated the hepatoprotective effect of purple potato extract ppe against dgalactosamine galn induced liver injury in rats.
Dietary glycine or pretreatment with gdcl 3 prevented these effects. The vehicle control group received orally administered normal saline. Ambrex was orally administered for a period of 7 days at dose levels of 250 and 500 mgkg b. Hepatoprotective effects of salidroside on fulminant. Protective effect of genistein on lipopolysaccharided. Effect of herbal preparation hp4 on the liver function tests as a marker of liver damage in dgalactosamine dgaln induced hepatotoxicity in mice units in iul s. Quercetin and srt1720 were dissolved in pure dmso dimethyl sulfoxide. Hepatoprotective activity of herbal preparation hp4.
Pdf dgalactosamine is a hepatotoxic agent, which induces diffuse injury of liver tissue followed by the regeneration process. Objective of this study was to obtain a better understanding of the mechanism responsible for the dgalactosamine dgaln induced hepatotoxicity and to study the effect of catechin against dgaln. In the present study, we evaluated the effect of alpha lipoic acid ala supplementation on acute galn induced oxidative liver injury. Inflammation and oxidative stress are essential for the pathogenesis of fulminant hepatic failure fhf. Pyropia yezoensis glycoprotein regulates antioxidant status and prevents hepatotoxicity in a rat model of dgalactosaminelipopolysaccharide induced acute liver failure. This study examines the role of pxr in lipopolysaccharide lpsd galactosamine galninduced acute liver injury using wildtype and.
Comparative effects of quercetin and srt1720 against d. Pdf hepatoprotective activity of lepidium sativum seeds. Treatment with boswellia ovalifoliolata root extracts has protected liver from induced hepatotoxicity. D galactosamine, hepatotoxicity, chang cells, antioxidants. Hepatotoxicity in dgalactosamine induced acute liver injury in rats nahid rahman1, munmun pervin1, mizuki kuramochi1, mohammad r. Pdf hepatotoxic effect of dgalactosamine and protective role of. The combination of lps and dgalactosamine galn is used experimentally to induce acute liver injury similar to fhf observed clinically. The protective role of pregnane x receptor in lipopolysaccharide d. This study examined the hepatoprotective effect of the hvp411 complex, an herbal extract mixture from the seeds of vitis vinifera, schisandra chinensis and taraxacum officinale, against dgalactosamine dgaln induced hepatitis. Attenuation of oxidative stress and hepatotoxicity induced by dgalactosamine by a polyherbal formulation ambrexin vivo and in vitro studies. These results strongly suggest the involvement of sirt1 in the cytoprotective effects of quercetin and srt1720 against dgalnlps induced hepatotoxicity.
Lps in combination with dgalninduced liver injury is a wellknown. Dgalactosamine is an amino sugar derivative of dgalactose item no. All these findings indicate a protective effect of lipid emulsion administration against dgalactosamine toxicity. Pyropia yezoensis glycoprotein regulates antioxidant. Silymarin is standardized hepatoprotective extract of silybum marianum compositae.
Previous studies on bifidobacterium longum r0175 have mainly focused on its psychotropic functions. The current research focused on the protective efficacy of b. Administration of tolllike receptor ligands tlrls is known to cause liver injury in dgalnsensitized mice. Acute liver failure is a severe liver disorder that poses considerable global challenges. Hepatoprotective activity of lepidium sativum seeds against dgalactosamine lipopolysaccharide induced hepatotoxicity in animal model. Hepatoprotective effect of pentoxifylline against dgalactosamine induced hepatotoxicity in rats. Protective effect of pinitol against dgalactosamine. Karim1, takeshi izawa1, mitsuru kuwamura1, and jyoji yamate1 abstract dgalactosamine dgaln is a wellknown hepatotoxic agent that causes liver injury. This study examines the role of pxr in lipopolysaccharide lpsdgalactosamine galninduced acute liver injury using wildtype and. Herbal medicines are in nice demand within the developed additionally as developing countries for primary aid due to their wide biological and medicative activities, higher safety margins, and. The effect of oral administration of a preparation of human urine phu on acute liver injury was examined in rats intoxicated with acetaminophen and dgalactosamine. In the present study herbal preparation or hp4 is a combination of 80% alcoholic extract of leaves of aloe vera, bacopa monniera, moringa oleifera and rhizome of zingiber officinale has been utilized. Effect of carvacrol on hepatic marker enzymes and antioxidant status in d.
Protective effect of xuebijing injection on dgalactosamine and. Muntanerole of nfkappab activation and nitric oxide expression during pge1 protection against dgalactosamine induced. Moreover, quercetin was more efficacious than srt1720 in combatting the cytotoxic effects of dgalnlps, as evidenced by lower markers of liver injury. Acetylbergenin was administered orally once daily for 7 days and then galn. Hepatoprotective activity of santolina chamaecyparissus. Pdf hepatoprotective effect of pentoxifylline against d. The inhibitory action of pdcd4 in lipopolysaccharided. The results indicated that phu protected the liver from acetaminophen and dgalactosamine induced injury as judged by morphological and biochemical observation. Shengchanges of gut flora and endotoxin in rats with dgalactosamine induced acute liver failure.
115 274 1339 1508 1044 30 561 792 650 1299 881 654 740 1333 869 1128 618 640 828 1270 1162 353 680 1031 1180 1213 694 880 188 1354 707 161 1356